Cheap flights from Destin to Panama City from $262

Travelers frequently search for route combinations, such as Destin and Boston, New York, Las Vegas, Calgary, Ontario, Phoenix, Indianapolis, Belleville, Oklahoma City, Wichita, Pittsburgh, Knoxville, Kansas City, Denver, Minneapolis, Billings, Oakland, Huntsville, Columbus, Orlando.

Travelers frequently search for route combinations, such as Panama and Houston, Los Angeles, New York, Miami, Atlanta, Dallas, Bocas Town, Bocas del Toro, Washington, D.C., San José, Detroit, San Juan, Orlando, Medellín, David, Chiriquí, San Francisco, Salt Lake City, Las Vegas, Chicago, Guatemala City, Bogotá.

The main airport in Destin is Destin–Fort Walton Beach. It is also served by Destin–Fort Walton Beach, Pensacola International, Gulfport–Biloxi International, Tallahassee International, Northwest Florida Beaches International, Mobile Regional, Dothan Regional, Montgomery Regional.

The main airport in Panama is Tocumen International. It is also served by Chitre Alonso Valderrama.

Currently, you can fly between Destin and Panama with Allegiant Air, Copa Airlines, Spirit Airlines, Avianca, Wingo airlines.

If you don’t have specific dates for your trip between Destin and Panama, you can enter a date range into the departure and return fields. Most carriers on the Kiwi.com website allow you to search and book up to six months from the day of your search. Order the search results by the best, cheapest, or fastest route, or find the cheapest outbound and return combination in the pricing table.

Traveling between Destin and Panama, you can choose between direct (nonstop) flights or flights with one or more stops. You can select the number of stops on your journey, including an overnight stopover, and the duration of the stopover. What’s more, you can also select where you want to have your stopover. Want to say "Hi" to a friend in another city en route to your destination? Or fancy a quick round of shopping? Go Multi-City or Nomad and add places to your search that you wish to visit.

There are a number of airports in and around Destin. The main one is Destin–Fort Walton Beach and other nearby airports include Destin–Fort Walton Beach, Pensacola International, Gulfport–Biloxi International, Tallahassee International, Northwest Florida Beaches International, Mobile Regional, Dothan Regional, Montgomery Regional

There are a number of airports in and around Panama. The main one is Tocumen International and other nearby airports include Chitre Alonso Valderrama.