Cheap flights from Des Moines to Myrtle Beach from $289

Travelers frequently search for route combinations, such as Des Moines and Phoenix, Fort Lauderdale, Orlando, New York, Salt Lake City, Miami, Mexico City, Los Angeles, Las Vegas, San Francisco, Milan, Santa Ana, Washington, D.C., San Diego, Boston, Punta Gorda, London, León, Toronto, Paris.

Travelers frequently search for route combinations, such as Myrtle Beach and New York, Boston, Hartford, Philadelphia, Pittsburgh, Denver, Providence, Cleveland, Chicago, Detroit, Cancún, Minneapolis, Orlando, Fort Lauderdale, Kingston, Cincinnati, Huntington, Bogotá, Las Vegas, Atlanta.

The main airport in Des Moines is Des Moines International. It is also served by Eppley Airfield, Des Moines International, The Eastern Iowa, Kirksville Regional, Southeast Iowa Regional, Mason City Municipal, Sioux Gateway, Fort Dodge Regional, Waterloo Regional.

The main airport in Myrtle Beach is Myrtle Beach International. It is also served by Raleigh–Durham International, Charleston International, Myrtle Beach International, Wilmington International, Columbia Metropolitan, Coastal Carolina Regional, Albert J. Ellis, Florence Regional, Fayetteville Regional.

Currently, you can fly between Des Moines and Myrtle Beach with United Airlines.

If you don’t have specific dates for your trip between Des Moines and Myrtle Beach, you can enter a date range into the departure and return fields. Most carriers on the Kiwi.com website allow you to search and book up to six months from the day of your search. Order the search results by the best, cheapest, or fastest route, or find the cheapest outbound and return combination in the pricing table.

Traveling between Des Moines and Myrtle Beach, you can choose between direct (nonstop) flights or flights with one or more stops. You can select the number of stops on your journey, including an overnight stopover, and the duration of the stopover. What’s more, you can also select where you want to have your stopover. Want to say "Hi" to a friend in another city en route to your destination? Or fancy a quick round of shopping? Go Multi-City or Nomad and add places to your search that you wish to visit.

There are a number of airports in and around Des Moines. The main one is Des Moines International and other nearby airports include Eppley Airfield, Des Moines International, The Eastern Iowa, Kirksville Regional, Southeast Iowa Regional, Mason City Municipal, Sioux Gateway, Fort Dodge Regional, Waterloo Regional

There are a number of airports in and around Myrtle Beach. The main one is Myrtle Beach International and other nearby airports include Raleigh–Durham International, Charleston International, Myrtle Beach International, Wilmington International, Columbia Metropolitan, Coastal Carolina Regional, Albert J. Ellis, Florence Regional, Fayetteville Regional.