Cheap flights from Des Moines to Greenville from $183

Travelers frequently search for route combinations, such as Des Moines and Phoenix, Fort Lauderdale, Orlando, New York, Salt Lake City, Miami, Mexico City, Los Angeles, Las Vegas, San Francisco, Milan, Santa Ana, Washington, D.C., San Diego, Boston, Punta Gorda, London, León, Toronto, Paris.

Travelers frequently search for route combinations, such as Greenville and Orlando, Fort Lauderdale, Los Angeles, Dallas, Edinburgh, San Diego, Flint, Minneapolis, Chicago, Oakland, St. Louis, Asheville, Medellín, Tampa, South Bend, Dayton, Fargo, Owensboro, Roanoke, Kansas City.

The main airport in Des Moines is Des Moines International. It is also served by Des Moines International, Eppley Airfield, The Eastern Iowa, Kirksville Regional, Mason City Municipal, Southeast Iowa Regional, Sioux Gateway, Fort Dodge Regional, Waterloo Regional.

The main airport in Greenville is Greenville–Spartanburg International. It is also served by Hartsfield–Jackson Atlanta International, Charlotte Douglas International, McGhee Tyson, Asheville Regional, Greenville–Spartanburg International, Columbia Metropolitan, Concord Regional, Augusta Regional, Tri-Cities Regional.

Currently, you can fly between Des Moines and Greenville with United Airlines.

If you don’t have specific dates for your trip between Des Moines and Greenville, you can enter a date range into the departure and return fields. Most carriers on the Kiwi.com website allow you to search and book up to six months from the day of your search. Order the search results by the best, cheapest, or fastest route, or find the cheapest outbound and return combination in the pricing table.

Traveling between Des Moines and Greenville, you can choose between direct (nonstop) flights or flights with one or more stops. You can select the number of stops on your journey, including an overnight stopover, and the duration of the stopover. What’s more, you can also select where you want to have your stopover. Want to say "Hi" to a friend in another city en route to your destination? Or fancy a quick round of shopping? Go Multi-City or Nomad and add places to your search that you wish to visit.

There are a number of airports in and around Des Moines. The main one is Des Moines International and other nearby airports include Des Moines International, Eppley Airfield, The Eastern Iowa, Kirksville Regional, Mason City Municipal, Southeast Iowa Regional, Sioux Gateway, Fort Dodge Regional, Waterloo Regional

There are a number of airports in and around Greenville. The main one is Greenville–Spartanburg International and other nearby airports include Hartsfield–Jackson Atlanta International, Charlotte Douglas International, McGhee Tyson, Asheville Regional, Greenville–Spartanburg International, Columbia Metropolitan, Concord Regional, Augusta Regional, Tri-Cities Regional.